- Complex Models of Human Brain Disease
- Automation-Enabled Systems Biology
- Machine Learning and Advanced Analytics
Complex Models of Human Brain Disease
We utilize stem cell and organoid technologies to generate complex in vitro models of human brain disease. By starting with patient-derived stem cells, we capture both known and latent genetic disease drivers. Our advanced organoid technologies enable the expression of uniquely human physiology, cellular diversity and tissue architecture through scalable brain models. Collectively, our approach provides an illuminating view into human-specific disease biology and unlocks a new wave of neuro drug discovery.
Automation-Enabled Systems Biology
Automation and scaled biology lie at the heart of our approach to drug discovery. Our integrated automation, software and analytics platform enables long-term culture and assay of thousands of organoids, enabling us to harness the biological richness of brain organoid models and phenotypically characterize neurological and psychiatric disease across the biological hierarchy, from genetics to neural network dynamics.
Machine Learning and Advanced Analytics
We apply leading-edge data analytics and machine learning approaches to integrate large scale high-dimensional phenotypic datasets and create comprehensive systems biology descriptions of brain disease. These “Deep Phenotypes” lie at the core of our drug discovery approach and reveal paths to new disease-modifying therapeutics for brain diseases with greater probability of clinical success. Deep Phenotypes provide continued support throughout the drug development process, inform translational research, companion diagnostic development, patient stratification and clinical trial design.